Breaking down barriers to improve phage therapy delivery – research by scientists at the Laboratory of Phage Molecular Biology

We are delighted to announce publication worth 200 points, which provides a synthesis of current knowledge in the field of bacteriophage pharmacokinetics and immunogenicity. The paper “Breaking down barriers to improve phage therapy delivery,” was published in the journal Cell Host & Microbe (IF 23.2). Authors from the Hirszfeld IIET PAS are Prof. Krystyna Dąbrowska, Ph.D., and Izabela Rybicka, MSc., from the Laboratory of Phage Molecular Biology.

There is growing interest in the development of bacteriophages as therapies for antimicrobial-resistant infections, but effective delivery of phages remains a barrier. This review examines the opportunities and challenges involved in the development of phages as drugs, focusing on phage delivery. The conclusion is that optimizing delivery is a key determinant of the success of phage therapy and that the integration of microbiology, materials science, and pharmacology will enable more consistent success.

Link to the article: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(26)00273-8