We are pleased to announce that a paper titled ‘Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells’ has been published in the Journal of Extracellular Vesicles (200 points MNiSW, IF 15.5). The co-authors of the paper are Agnieszka Razim, PhD, Agnieszka Zablocka, DSc and Sabina Gorska, DSc from the Microbiome Immunobiology Laboratory. The paper shows that bacterial extracellular vesicles may be a safer alternative to live strains in clinical applications. The extracellular vesicles of the probiotic E. coli strain O83 were characterised in detail and shown to interact with the nasal mucosa, efficiently induce signalling pathways and be engulfed by macrophages. The next step will be to investigate their use in mucosal vaccines and immunotherapy.
The work was developed in collaboration with a number of centres: Medical University of Vienna, Aarhus University, Jagiellonian University, Karolinska Institute, Charles University in Prague, Institute of Nanostructured Materials in Bologna and the Czech Academy of Sciences, under, among others, the MSCA-PF grant of Agnieszka Razim, PhD and the NAWA grant PPN/BAT/2021/1/00004/U/00001 of Sabina Gorska, DSc.
https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70004