Research group of the Laboratory of Biology of Stem and Neoplastic Cells is focusing in the biological properties of somatic mesenchymal stem cells (MSC) and progenitor cells residing in the adult tissues in order to use their biological potential in the regeneration of tissues and organs.
Research in the field of regenerative medicine:
Research related to tissue distribution, isolation and characterization of mesenchymal stem cells and tissue-specific progenitor cells residing in the human tissues and organs. The aim of ongoing research is characterization of tissue-specific stem/progenitor cells for potential clinical application in regenerative medicine.- Preclinical studies on biological activity of MSCs secretome (bioactive factors and extracellular vesicles secreted by MSCs) in regenerative processes.
- Studies on the new generation dressing containing a mixture of bioactive factors secreted by mesenchymal stem cells of adipose tissue-origin (atMSC) for the treatment of chronic wounds.
- Studies on the osteogenic potential of MSCs seeded on the scaffolds in order to create a bioimplant for the reconstruction of large bone defects
- isolation and characterization of cancer stem cells
- studies of mechanisms related to the cancer metastasis or inhibition of tumour growth
Head
Head: Aleksandra Klimczak, PhD, DSc, Professor (Professor, ORCID 0000-0001-6590-4420)
Professor Aleksandra Klimczak, graduated Wroclaw Medical Academy, Div. Pharmacy and Medical Laboratory Sciences. She obtained the PhD doctoral degree and habilitation at the Institute of Immunology and Experimental Therapy PAS in Wroclaw. She gained experience and skills in Poland and in international institutions. In the years 1998-2002 she cooperated with the Institute Paris-Sud sur les Cytokines INSERM U131 in France. In 2003-2009, at the Cleveland Clinic Foundation, USA, she participate in the pioneering experimental research of breakthrough importance in reconstructive and transplant medicine.
Her scientific activity is associated with a wide range of research related to transplant immunology, regenerative medicine and stem cell biology, both in experimental models and in clinical applications.
Earlier research by Professor Klimczak, related to transplant immunology, significantly contributed to understanding the mechanisms of immune tolerance in cell transplantation and in composite tissue allografts. Currently, Professor Klimczak conducts intensive research on the biology of somatic mesenchymal stem cells residing in the tissues of an adult organism in the context of using their biological potential in regenerative medicine. Moreover, she also conducting research on the biology of cancer stem cells.
Professor Aleksandra Klimczak, graduated Wroclaw Medical Academy, Div. Pharmacy and Medical Laboratory Sciences. She obtained the PhD doctoral degree and habilitation at the Institute of Immunology and Experimental Therapy PAS in Wroclaw. She gained experience and skills in Poland and in international institutions. In the years 1998-2002 she cooperated with the Institute Paris-Sud sur les Cytokines INSERM U131 in France. In 2003-2009, at the Cleveland Clinic Foundation, USA, she participate in the pioneering experimental research of breakthrough importance in reconstructive and transplant medicine.
Her scientific activity is associated with a wide range of research related to transplant immunology, regenerative medicine and stem cell biology, both in experimental models and in clinical applications.
Earlier research by Professor Klimczak, related to transplant immunology, significantly contributed to understanding the mechanisms of immune tolerance in cell transplantation and in composite tissue allografts. Currently, Professor Klimczak conducts intensive research on the biology of somatic mesenchymal stem cells residing in the tissues of an adult organism in the context of using their biological potential in regenerative medicine. Moreover, she also conducting research on the biology of cancer stem cells.