Laboratory of Biomedical Chemistry is a place where chemistry meets biology. We conduct interdisciplinary research that allows us to synthesize and characterize new molecules in a way typical to chemist but we put emphasis on possible therapeutic use of molecules designed here. Many of our projects contribute to basic research but we endeavor to create molecules which have various biological activities or have high value as a diagnostic tools, therefore our results could be translated for further use. Our team currently is focused on:
- using icosahedral boron clusters as new, inorganic entities that could be used for modification of various biological molecules (eg. drugs, proteins). We synthesize small boron cluster derivatives and macromolecular bioconjugates to study influence of new boron component on their original activity. We also investigate possible use of boron-derived molecules in biological applications.
- developing potent boron carriers for boron neutron capture therapy (BNCT). Boron neutron capture therapy is a type of targeted radiotherapy of tumors where 10B isotope is selectively delivered to malignant cells. Those cells are later exposed to neutron beam. In this process, alpha particles are generated that destroy cancer cells. This kind of radiation is space limited, and affects only malignancy and cells in very close vicinity. Our focus is to design boron rich molecules that target cancer cells selectively.
- Synthesizing of macromolecular drug – carrier conjugates for anticancer therapy with particular emphasis on polysaccharide carriers.
- Searching for new alternatives in combating bacterial infections. The experiments on the physicochemistry of bacteriophages continued in our laboratory may contribute to the development of effective methods of stabilizing viruses in preparations dedicated to biotechnology. The physicochemical characteristics of bacterial viruses enable a broader look at their biology and analysis of behavior in various environments.